Innovative Methodology Side-selective, unobtrusive monitoring of nasal airflow and conductance

Kohler, Malcolm, Robert Thurnheer, and Konrad E. Bloch. Side-selective, unobtrusive monitoring of nasal airflow and conductance. J Appl Physiol 101: 1760–1765, 2006. First published July 13, 2006; doi:10.1152/japplphysiol.00517.2006.—Whether nasal obstruction disturbs sleep and nocturnal breathing is controversial because convenient techniques for measuring nasal resistance during sleep are lacking. Therefore, we developed a technique for unobtrusive, sideselective nasal conductance monitoring. The technique measures left and right nasal airflow and transnasal pressure using nasal cannulas, thin catheters inserted through the cannulas into the nasopharynx, and three pressure transducers. Their processed signals provide conductance as airflow-to-resistive pressure ratio for the left and right side and the sum, total nasal conductance. For validation, total nasal conductance was also determined by a flowmeter attached to a nasal mask and nasopharyngeal pressure that served as reference standard. Methods were compared in five normal subjects during pharmacological interventions and in 12 snorers during sleep. The novel technique accurately tracked total nasal conductance by the reference method at baseline, after nasal application of histamine and xylomethazoline in normal subjects; mean difference (bias) was 1%, and limits of agreement ( 2 SD of bias) were 22% (75 comparisons). Corresponding values during overnight sleep studies in snorers were 0 19% (192 comparisons); bias and limits of agreement of changes in nasal conductance were 1 19% (180 comparisons). Conductance measured once at the beginning of sleep studies differed from subsequent measurements during the night by a mean SD of 26 20%, P 0.0001. The novel technique accurately measures side-selective conductance. It is suitable to investigate interactions among nasal obstruction, sleep and nocturnal breathing, and drug effects. One-time measurements at the beginning of sleep studies do not appropriately reflect the highly variable nasal conductance during an entire night.